Global Advanced Research Journal of Environmental Science and Toxicology (GARJEST) ISSN: 2315-5140
November 2014 Vol. 3(4), pp. 049-056
Copyright © 2014 Global Advanced Research Journals

Full Length Research Paper

Effects of Leurus quinquestriatus scorpion venom on the histological structure of the liver and kidney

Al–Harbi, H.A.A.¹ and Al-Hasawi, Z.M.^2*

¹Poison Control and Medical Forensic Toxicology Center, Jeddah, Saudi Arabia
²Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia

*Corresponding Author`s E-mail: ahssan555@yahoo.com

Abstract

The present study was planned to examine the effect of the venom of the yellow scorpion Leurus quinquestriatus (Arachnoida) venom on the histological structure of the liver and kidney of albino mice. Ten albino mice with the same age (45 days)and approximately the same the same body weight (25±5 gm) were used . The venom was obtained from L.quinquestrianus which was collected from Al-Khomra area near Jeddah City, by means of an electric stimulation . The mice were subjected to intercellular injections with the scorpion venom with a dose of 0.03 mg/km , and the animals were left 6 hours before being dissected . The animals were anaethetised with diethyl ether ,dissected and small parts of the liver and kidney were removed. Michrotmic sections were made and three materials were used to stain the sections , each specialized in certain characteristics. The venom caused remarkable histological alterations in the liver and kidney tissue structure, like nuclear margination, nuclear pyknosis, karyolysis, cell swelling, cellular necrosis, cellular damage, and inactivation of the antigen marking the endothelial clls (CD34).

Keywords: Yellow scorpion - venom - histological structure- liver – kidney- albino mice.