Potential modulatory role of Glycyrrhiza glabra against hepatic morbidity in chronic murine schistosomiasis

Global Advanced Research Journal of Educational Research and Reviews (GARJERR) ISSN: 2315-5132

February 2017, 6(1): pp. 005-011

Full Length Research Paper

Potential modulatory role of Glycyrrhiza glabra against hepatic morbidity in chronic murine schistosomiasis

Soheir Mahmoud^a, Neimat Amer^a, Nevine Guirguis^a, Ahmed H. Helmy^b, Maisa Shalaby^a, Wafaa Elkomy^a and Hoda Sabry^a

Parasitology^a and Surgery^b Departments Theodor Bilharz Research Institute

Corresponding Author Email: nevinenessimtadros@gmail.com

Accepted 27 February, 2017

Abstract

This work is a trial to elucidate the effect of liquorice root extract (G.glabra) on the course of chronic hepatic schistosomiasis mansoni. Sixty Swiss Albino mice were used in the experiment. Animals were divided into 6 groups. Group1- chronically infected for 16 weeks. Group 2- chronically infected for 16 weeks and treated with both G. glabra (1st week post infection) and praziquantel (PZQ) (6th week post infection). Group 3- infected mice given G glabra starting from the1st till the16th week P I. Group 4- animals received PZQ on the 16th week P I for two consecutive days. Group 5- normal un infected non treated mice. Group 6- normal non infected mice given G glabra for 16 weeks. All groups were sacrificed 16 weeks P I. Histopathological studies of the liver were done for granuloma measurments. Serum Alanine Aminotransferase (ALT), Aspartate Aminotransferase (AST) and transforming Growth Factor Beta One (TGFb1) were calculated. Mice given the combination regimen revealed complete eradication of worms 16 weeks post infection (P. I), with vanishing of both mature and immature ova in the oogram, and minimal hepatic granuloma diameter. Again, G glabra given with praziquantel (PZQ) normalized the level of both serum liver enzymes, (ALT) and (AST), and (TGF-β1). The data recorded in this group (2), were significantly comparable to the infected control group. PZQ remarkably improved parasitological parameters. The promising impact on liver morbidity could be attributed to the protective role of liquorice against inflammation and oxidative stress. This study could be of value in endemic areas where schistosomiasis mansoni is a devastating public health insult to the community.

Keywords: Chronic schistosomiasis mansoni, hepatic granuloma, liquorice, praziquantel (PZQ) , Alanine Aminotransferase (ALT) ,Aspartate Aminotransferase (AST) and Transforming Growth Factor beta one (TGFb1).

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